The Mizoroki-Heck Reaction

• mechanisms of the Mizoroki-Heck reaction
• intermolecular Mizoroki-Heck reactions
• focus on regioselectivity and product outcome in organic synthesis
• waste-minimized Mizoroki-Heck reactions
• intramolecular Mizoroki-Heck reactions
• formation of heterocycles
• chelation-controlled Mizoroki-Heck reactions
• the Mizoroki-Heck reaction in domino processes
• oxidative heck-type reactions (Fujiwara-Moritani reactions)
• Mizoroki-Heck reactions with metals other than palladium
• ligand design for intermolecular asymmetric Mizoroki-Heck reactions
• intramolecular enantioselective Mizoroki-Heck reactions
• desymmetrizing Mizoroki-Heck reactions
• applications in combinatorial and solid phase syntheses, and the development of modern solvent systems and reaction techniques
• the asymmetric intramolecular Mizoroki-Heck reaction in natural product total synthesis

Several chapters are devoted to asymmetric Heck reactions with particular focus on the construction of otherwise difficult-to-obtain sterically congested tertiary and quaternary carbons. Industrial and academic applications are highlighted in the final section. The Mizoroki-Heck Reaction will find a place on the bookshelves of any organic or organometallic chemist.